Principal Member of the Technical Staff
Biotechnology and Bioengineering Department
(925) 294-2922 / dysasak@sandia.gov
Research Interests
Our research focuses around chemical recogntion and molecular self-assembly to generate unique two- and three-dimensional materials for sensing, nanoarchitecture, and biocompatible materials. The materials are prepared from uniquely functionalized amphiphilic molecules that form lipid membranes, Langmuir films, self-assembled monolayers, and hydrocarbon-fluorocarbon micellar and bilayer materials. The amphiphiles are synthetically prepared in our laboratory with receptors for the selective capture of specific analytes and with fluorescent tags for spectroscopic monitoring of the amphiphiles as they mobilize within the membrane. Chemical recognition is used as a stimulant to actuate molecular reorganization in the two-dimensional structures of lipid membranes providing a means to control and define nanoscale structures in two- and three-dimensions.
I am an investigator in the Sandia Bioassemblies Group. Visit our website to learn more about our ongoing projects and collaborations.
2010 – present
- Kent, Michael S., Jaclyn K. Murton, Darryl Y. Sasaki, Sushil Satija,
Bulent Akgun, Hirsh Nanda, Joseph E. Curtis, Jaroslaw Majewski, Christopher R.
Morgan, John R. Engen, (2010) Neutron Reflectometry Study of the Conformation of HIV Nef Bound to Lipid Membranes,
Biophys. J., 99:1940.
- Siu, H, J Duhamel, DY Sasaki, JL Pincus. (2010). Nanodomain Formation in Lipid Membranes Probed by Time-Resolved Fluorescence. Langmuir 26(13):10985.
- Stachowiak, JC, CC Hayden, DY Sasaki. (2010). Steric Confinement of Proteins on Lipid Membranes Can Drive Curvature and Tubulation. Proceedings of the National Academy of Sciences of the United States of America 107(17):7781.
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2000 – 2009
- Lee, SE, DY Sasaki, TD Perroud, D Yoo, KD Patel, LP Lee. (2009). Biologically Functional Cationic Phospholipid-Gold Nanoplasmonic Carriers of RNA. Journal of the American Chemical Society 131(39):14066.
- Yip, CM, MS Kent, DY Sasaki. (2009). Protein-Membrane Interactions on Supported Lipid Membranes. Soft Nanomaterials, H.S. Nalwa (Ed.), American Scientific Publishers, Stevenson Ranch, 2:67.
- Hayden, CC, JS Hwang, EA Abate, MSKent, DY Sasaki. (2009). Directed Formation of Lipid Membrane Microdomains as High Affinity Sites for His-Tagged Proteins. Journal of the American Chemical Society 131(25):8728.
- Orendorff, CJ, TM Alam, DY Sasaki, BC Bunker, JA Voigt. (2009). Phospholipid-Gold Nanorod Composites. ACS Nano 3:971.
- Spoerke, ED, GD Bachand, J Liu, DY Sasaki, BC Bunker. (2008). Directing the Polar Organization of Microtubules. Langmuir 24:7039.
- Gourley, PL, DY Sasaki, RK Naviaux. (2008). Nanolaser spectroscopy for studying novel biomaterials. Proceedings of SPIE 6859:685914/1.
- Liu, H, GD Bachand, H Kim, CC Hayden, EA Abate, DY Sasaki. (2008). Lipid Nanotube Formation from Streptavidin-Membrane Binding. Langmuir 24:3686.
- Kent, MS, H Yim, JK Murton, DY Sasaki, BD Polizzotti, MB Charati, KL Kiick, I Kuzmenko, S Satija. (2008). Synthetic Polypeptide Adsorption to Cu-IDA Containing Lipid Films: A Model for Protein-Membrane Interactions. Langmuir 24:932.
- Slade, AL, JS Schoeniger, DY Sasaki, CM Yip. (2006). In Situ Scanning Probe Microscopy Studies of Tetanus Toxin-Membrane Interactions. Biophysical Journal 91:4565.
- Suzuki, T, YW Zhang, T Koyama, DY Sasaki, K Kurihara. (2006). Direct Observation of Substrate-Enzyme Complexation by Surface Forces Measurement. Journal of the American Chemical Society 128:15209.
- Zeineldin, R, JA Last, AL Slade, LK Ista, P Bisong, MJ O’Brien, SRJ Brueck, DY Sasaki, GP Lopez. (2006). Using Bicellar Mixtures to Form Supported and Suspended Lipid Bilayers on Silicon Chips. Langmuir 22:8163.
- Sasaki, DY, MJ Stevens. (2006). Stacked, Folded, and Bent Lipid Membranes. MRS Bulletin July issue:521. (Invited review article in Special Issue on Materials Science of Supported Lipid Membranes).
- Yim, H, MS Kent, DY Sasaki, BD Polizzotti, KL Kiick, J Majewski, S Satija. (2006). Rearrangement of Lipid Ordered Phases Upon Protein Adsorption Due to Multiple Site Binding. Physical Review Letters 96(19):198101/1.
- Song, Y, WA Steen, D Peña, YB Jiang, CJ Medforth, Q Huo, JL Pincus, Y Qiu, DY Sasaki, JE Miller, JA Shelnutt. (2006). Foamlike Nanostructures Created from Dendritic Platinum Sheets on Liposomes. Chemistry of Materials 18:2335.
- Kent, MS, H Yim, DY Sasaki, S Satija, YS Seo, J Majewski. (2005). Adsorption of Myoglobin to Cu(II)-IDA and Ni(II)-IDA Functionalized Langmuir Monolayers: Study of the Protein Layer Structure during the Adsorption Process by Neutron and X-Ray Reflectivity. Langmuir 21:6815.
- Pincus, JL, C Jin, W Huang, HK Jacobs, AS Gopalan, Y Song, JA Shelnutt, DY Sasaki. (2005). Selective fluorescence detection of divalent and trivalent metal ions with functionalized lipid membranes. Journal of Materials Chemistry 15:2938. (Invited article in Special Issue of Fluorescence Sensors).
- Carpick, RW, AR Burns, DY Sasaki, MA Eriksson, MS Marcus. (2005). Chromic transitions and nanomechanical properties of poly(diacetylene) molecular films. ACS Symposium Series 888 (Chromogenic Phenomena in Polymers):82.
- Peterson, SL, A McDonald, PL Gourley, DY Sasaki. (2005). Poly(dimethylsiloxane) thin films as biocompatible coatings for microfluidic devices: Cell culture and flow studies with glial cells. Journal of Biomedical Materials Research 72A(1):10.
- Carpick, RW, DY Sasaki, MS Marcus, MA Ericksson, AR Burns. (2004). Polydiacetylene Films: A Review of Recent Investigations into Chromogenic Transitions and Nanomechanical Properties. Journal of Physics: Condensed Matter 16:R679.
- Suzuki, T, YW Zhang, T Koyama, DY Sasaki, K Kurihara. (2004). Direct observation of specific interaction between enzyme-substrate complexes using colloidal probe atomic force microscopy. Chemistry Letters 33:536.
- Pandey, S, RA Redden, KA Fletcher, DY Sasaki, AE Kaifer, GA Baker. (2004). Generation and pH dependent superquenching of poly(amido) carboxylate dendrons hosting a single “focal point” pyrene. Chemical Communications 11:1318.
- Kent, MS, H Yim, DY Sasaki, S Satija, J Majewski, T Gog. (2004). Analysis of Myoglobin Adsorption to Cu(II)-IDA and Ni(II)-IDA Functionalized Langmuir Monolayers by Grazing Incidence Neutron and X-ray Techniques. Langmuir 20:2819.
- Huang, W, C Jin, DK Derzon, TA Huber, JA Last, PP Provencio, AS Gopalan, M Dugger, DY Sasaki. (2004). Synthesis of ether-linked fluorocarbon surfactants and their aggregational properties in organic solvents. Journal of Colloid and Interface Science 272:457.
- Gaudioso, J, DY Sasaki. (2004). Nanostructure and Dynamic Organization of Lipid Membranes. Encyclopedia of Nanoscience and Nanotechnology JA Schwarz, CI Contescu, K Putyera, Eds., Marcel Dekker Inc.: New York, pp. 2507–2517 (Invited chapter).
- Jiang, L, RC Hughes, DY Sasaki. (2004). Supramolecular assembly of a quaterthiophene surfactant. Chemical Communications 1028.
- Sasaki, DY. (2003). Control of membrane structure and organization through chemical recognition. Cell Biochemistry and Biophysics 39:145 (Invited review article).
- Marcus, MS, MA Eriksson, DY Sasaki, RW Carpick. (2003). In-plane contributions to phase contrast in intermittent contact atomic force microscopy. Ultramicroscopy 97:145.
- Carpick, RW, MS Marcus, MJ D’lAmato, DY Sasaki, MA Eriksson. (2003). Nanometer-scale studies of anisotropic polymer surfaces. Polymeric Materials: Science and Engineering 88:499.
- Bondurant, B, JA Last, TA Waggoner, A Slade, DY Sasaki. (2003). Optical and Scanning Probe Analysis of Glycolipid Reorganization upon Concanavalin A Binding to Mannose-Coated Lipid Bilayers. Langmuir 19:1829 (Invited article – Special issue on The Biomaterial Interface).
- Yang, Y, Y Lu, M Lu, J Huang, R Haddad, G Xomeritakis, N Liu, AP Malanoski, D Sturmayr, H Fan, DY Sasaki, RA Assink, JA Shelnutt, FV Swol, GP Lopez, AR Burns, CF Brinker. (2003). Functional Nanocomposites Prepared by Self-Assembly and Polymerization of Diacetylene Surfactants and Silicic Acid. Journal of the American Chemical Society 125(5):1269.
- Gourley, PL, RG Copeland, JD Cox, JK Hendricks, AE McDonald, SL Peterson, DY Sasaki. (2002). Biocompatible semiconductor optoelectronics. Journal of Biomedical Optics 7(4):546.
- Gourley, PL, RG Copeland, JD Cox, JK Hendricks, AE McDonald, SL Peterson, DY Sasaki. (2002). Degradation of optoelectronic properties of semiconductors by biofluids and mitigation by polymer overlayers. Proceedings of the SPIE Published by The International Society for Optical Engineering, 4626(Biomedical Nanotechnology Architectures and Applications):357.
- Marcus, MS, RW Carpick, DY Sasaki, MA Ericksson. (2002). Material Anisotropy Revealed by Phase Contrast in Intermittent Contact Atomic Force Microscopy. Physical Review Letters 88:226103/1.
- Kent, MS, H Yim, DY Sasaki, J Majewski, GS Smith, K Shin, S Satija, BM Ocko. (2002). Segment Concentration Profile of Myoglobin Adsorbed to Metal Ion Chelating Lipid Monolayers at the Air-Water Interface by Neutron Reflection. Langmuir 18:3754.
- Sasaki, DY, TA Waggoner,JA Last, TM Alam. (2002). Crown Ether Functionalized Lipid Membranes: Lead Ion Recognition and Molecular Reorganization. Langmuir 18:3714.
- Cox, JD, MS Curry, SK Skirboll, PL Gourley, DY Sasaki. (2002). Surface passivation of a microfluidic device to glial cell adhesion: a comparison of hydrophobic and hydrophilic SAM coatings. Biomaterials 23:929.
- Last, JA, TA Waggoner, DY Sasaki. (2001). Lipid Membrane Reorganization Induced by Chemical Recognition. Biophysical Journal 81:2737.
- Sasaki, DY, JD Cox, SC Follstaedt, MS Curry, SK Skirboll, PL Gourley. (2001). Glial cell adhesion and protein adsorption on SAM coated semiconductor and glass surfaces of a microfluidic structure. Proceedings of the SPIE 4265:152.
- Burns, AR, RW Carpick, DY Sasaki, JA Shelnutt, R Haddad. (2001). Shear-induced mechanochromism in polydiacetylene monolayers. Tribology Letters 10:89.
- Lu, YF, Y Yang, A Sellinger, MC Lu, JM Huang, HY Fan, R Haddad, G Lopez, AR Burns, DY Sasaki, J Shelnutt, CJ Brinker. (2001). Self-assembly of mesoscopically ordered chromatic polydiacetylene/silica nanocomposites. Nature 410:913.
- Gourley, PL, DY Sasaki. (2001). Biocavity Lasers. American Scientist 9:152 (Invited article).
- Sasaki, DY. (2001). Molecular Imprinting Approaches Using Inorganic Matrices. In Molecularly Imprinted Polymers Sellergren, B., Ed.; Elsevier Science B.V.: Amsterdam, Vol. 23, pp 213–242 (Invited chapter).
- Waggoner, TA, JA Last, PG Kotula, DY Sasaki. (2001). Self-Assembled Columns of Stacked Lipid Bilayers Mediated by Metal Ion Recognition. Journal of the American Chemical Society123:496.
- Sasaki, DY, S Singh, JD Cox, PI Pohl. (2001). Fluorescence detection of nitrogen dioxide with perylene/PMMA thin films. Sensors and Actuators B 72:51.
- Kent, MS, Y Yim, DY Sasaki, J Majewski, GS Smith, K Shin, S Satija. (2001). Adsorption of myoglobin to metal ion-chelating lipid monolayers at the air-liquid interface by neutron reflection. Polymeric Materials: Science and Engineering 85:328.
- Sasaki, DY, RW Carpick, AR Burns. (2000). High Molecular Orientation in Mono- and Trilayer Polydiacetylene Films Imaged by Atomic Force Microscopy. Journal of Colloid and Interface Science 229:490.
- Carpick, RW, TM Mayer, DY Sasaki, AR Burns. (2000). Spectroscopic Ellipsometry and Fluorescence Study of Thermochromism in an Ultrathin Poly(diacetylene) Film: Reversibility and Transition Kinetics. Langmuir 16:4639.
- Sasaki, DY, TM Alam. (2000). Solid-State 31P NMR Study of Phosphonate Binding Sites in Guanidine-Functionalized, Molecular Imprinted Silica Xerogels. Chemistry of Materials 12:1400.
- Carpick, RW, DY Sasaki, AR Burns. (2000). First Observation of Mechanochromism at the Nanometer Scale. Langmuir 16:1270.
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1990 – 1999
- Carpick, RW, DY Sasaki, AR Burns. (1999). Large friction anisotropy of a polydiacetylene monolayer. Tribology Letters 7:79.
- Sasaki, DY, TA Waggoner. (1999). Optical detection of aqueous phase analytes via host-guest interactions on a lipid membrane surface. Proceedings of the SPIE 3606:46.
- Sasaki, DY, LE Shea, MB Sinclair. (1999). Thin-film silica sol-gels doped with ion responsive fluorescent lipid bilayers. Proceedings of the SPIE 3602:275.
- Ishiguro, R, DY Sasaki, C Pacheco, K Kurihara. (1999). Interaction forces between metal-chelating lipid monolayers measured by colloidal probe atomic force microscopy. Colloids and Surfaces 146:329.
- Singh, S, DY Sasaki, J Cesarano III, AJ Hurd. (1999). Nanometer Pores in Ultra-Thin Silica Films Prepared by Self-Assembly of Organic Spacers in an Alkylsiloxane Monolayer. Thin Solid Films 339:209.
- Matzke, CM, RJ Kottenstette, SA Casalnuovo, GC Frye-Mason, ML Hudson, DY Sasaki, RP Manginell, CC Wong. (1998). Microfabricated silicon gas chromatographic micro-channels: fabrication and performance. SPIE 3511:262.
- Sasaki, DY, BE Padilla. (1998). Dithioamide metal ion receptors on fluorescent lipid bilayers for the selective optical detection of mercuric ion. Chemical Communications 1581.
- Sasaki, DY, DJ Rush, TM Alam, RA Assink, CS Ashley, CJ Brinker, KJ Shea. (1998). Molecular Imprinted Receptors in Sol-Gel Materials for Aqueous Phase Recognition of Phosphates and Phosphonates. In ACS Symposium Series, Book 703, Molecular and Ion Recognition with Imprinted Polymers, RA Bartsch, M Maeda, Eds.; American Chemical Society: Washington, D.C., chapter 22.
- Yamanaka, SA, DH Charych, DA Loy, DY Sasaki. (1997). Solid Phase Immobilization of Optically Responsive Liposomes in Sol-Gel Materials for Chemical and Biological Sensing. Langmuir 13:5049.
- Maloney, KM, DR Shnek, DY Sasaki, FH Arnold. (1996). Fluorescence Signaling of Ligand Binding and Assembly in Metal-Chelating Lipid Membranes. Chemistry & Biology 3:185.
- Ng, K, DW Pack, DY Sasaki, FH Arnold. (1995). Engineering Protein-Lipid Interactions: Targeting of Histidine-tagged Proteins to Metal-Chelating Lipid Monolayers. Langmuir 11:4048.
- Sasaki, DY, DR Shnek, DW Pack, FH Arnold. (1995). Metal-Induced Dispersion of Lipid Aggregates: A Simple, Selective and Sensitive Fluorescent Metal Ion Sensor. Angewandte Chemie International Edition England 34:905.
- Kurihara, K, T Kawahara,DY Sasaki, K Ohto, T Kunitake. (1995). Elemental Analysis of Langmuir-Blodgett Films by X-ray Photoelectron Spectroscopy. Langmuir 11:1408.
- Shnek, DR, DW Pack, DY Sasaki, FH Arnold. (1994). Specific Protein Attachment to Artificial Membranes via Coordination to Lipid-Bound Copper(II). Langmuir 10:2382.
- Sano, M, DY Sasaki, S Yoshimura, T Kunitake. (1994). Polymerization-induced Epitaxy of Polylactones on Graphite as probed by Scanning Tunnelling Microscopy. Faraday Discuss 98:07.
- Sano, M, DY Sasaki, T Kunitake. (1993). Polymerization-Induced Epitaxy. Poly(vinylidene chloride) on Graphite by Free Radical Polymerization. Langmuir 9:629.
- Sasaki, DY, K Kurihara, T Kunitake (1992). Self-Assembled Multifunctional Receptors for Nucleotides at the Air-Water Interface. Journal of the American Chemical Society 114:10994.
- Shea, KJ, R O’Dell, DY Sasaki. (1992). Free Radical Induced Macrocyclizations. Tetrahedron Letters 33:4699.
- Sano, M, DY Sasaki, T Kunitake. (1992). Polymerization Induced Epitaxy. Polyether Film on Graphite as Studied by Scanning Tunnelling Microscopy. Journal of the Chemical Society – Chemical Communications 1326.
- Sano, M, DY Sasaki, T Kunitake. (1992). Polymerization Induced Epitaxy. Scanning Tunneling Microscopy of Hydrogen Bonded Sheet of Polyamide on Graphite. Toyoki Science 258:441.
- Sano, M, DY Sasaki, T Kunitake. (1992). Epitaxial Polymerization of Polyether as Studied by Scanning Tunneling Microscopy. Proceedings of the Japan Academy, Series B 68:87.
- Sano, M, DY Sasaki, T Kunitake. (1992). Structural Study of Polyethers on Graphite by Scanning Tunneling Microscopy. Polymerization Induced Epitaxy. Macromolecules 25:6961.
- Sano, M, DY Sasaki, M Isayama, T Kunitake. (1992). Interfacial and Bulk Structures of Homologous Series of Azobenzene Amphiphiles Studied by Scanning Tunneling Microscopy and X-ray Diffraction. Langmuir 8:1893.
- Sasaki, DY, M Yanagi, K Kurihara, T Kunitake. (1992). The Interaction of a Guanidinium Monolayer with ATP and AMP, as Revealed by Surface Potential and UV Absorption Measurements. Thin Solid Films 210/211:776.
- Jerábek, K, KJ Shea, DY Sasaki, GJ Stoddard. (1992). Accessibility of the Gel Phase in Macroporous Network Polymers: A Comparison of the Fluorescence Probe and Inverse Steric Exclusion Chromatography Techniques. Journal of Polymer Science Part A: Polymer Chemistry 30:605.
- Sasaki, DY, K Kurihara, T Kunitake. (1991). Specific, Multiple-Point Binding of ATP and AMP to a Guanidinium-Functionalized Monolayer. Journal of the American Chemical Society 113:9685.
- Shea, KJ, DY Sasaki. (1991). An Analysis of Small-Molecule Binding to Functionalized Synthetic Polymers by 13C CP/MAS NMR and FT-IR Spectroscopy. Journal of the American Chemical Society 113:4109.
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1980 – 1989
- Shea, KJ, DY Sasaki, GJ Stoddard. (1989). Fluorescence Probes for Evaluating Chain Solvation in Network Polymers. An Analysis of the Solvatochromic Shift of the Dansyl Probe in Macroporous Styrene-Divinylbenzene and Styrene-Diisopropenylbenzene Copolymers. Macromolecules 22(4):1722.
- Shea, KJ, GJ Stoddard, DY Sasaki. (1989). Fluorescence Probes for the Evaluation of Diffusion of Ionic Reagents Through Network Polymers. Chemical Quenching of the Fluorescence Emission of the Dansyl Probe in Macroporous Styrene-Divinylbenzene and Styrene-Diisopropenylbenzene Copolymers. Macromolecules 22:4303.
- Shea, KJ, DY Sasaki. (1989). On the Control of Microenvironment Shape of Functionalized Network Polymers Prepared by Template Polymerization. Journal of the American Chemical Society 111(9):3442.
- Shea, KJ, GJ Stoddard, DY Sasaki. (1987). Fluorescence Probes for the Study of Solvation and Diffusion of Reagents in Network Polymers. ACS Symposia Series, Book 358 J Torkelson, C Hoyle, Eds.; American Chemical Society: Washington, D.C.; chapter 9.
- Shea, KJ, DY Sasaki, GJ Stoddard. (1987). Characterization of Highly Crosslinked Networks by the Fluorescence Probe Technique. Polymer Preprints, American Chemical Society, Division of Polymer Chemistry 28(2):88.
- Shea, KJ, GJ Stoddard, DY Sasaki. (1986). Fluorescence Probes for the Study of Diffusion of Reagents in Network Polymers. Polymer Preprints, American Chemical Society, Division of Polymer Chemistry 27(2):344.
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- Sasaki, DY, TA Waggoner, JA Last. Self-Assembled Lipid Bilayer Materials. U.S. Patent 6,962,747. November 8, 2005.
- Charych, DH, SA Yamanaka, DY Sasaki. Sol-gel Matrices for Direct Colorimetric Detection of Analytes. U.S. Patent 6,485,987. November 26, 2002.
- Sasaki, DY. Molecular Receptors in Metal Oxide Sol-Gel Materials Prepared via Molecular Imprinting. U.S. Patent 6,057,377. May 2, 2000.
- Charych, DH, SA Yamanaka, DY Sasaki. Sol-gel Matrices for Direct Colorimetric Detection of Analytes. U.S. Patent 6,022,748. February 8, 2000.
- Yamanaka, SA, DY Sasaki, DA Loy. Immobilized Lipid-Bilayer Materials. U.S. Patent 6,048,546. April 11, 2000.
- Sasaki, DY, DR Shnek, DW Pack, FH Arnold. Metal Chelating Lipids Which are Useful as Sensors in Fluorometric Methods for the Detection of Metal Ions. U.S. Patent 5,837,202. November 17, 1998.
- Sasaki, DY, DR Shnek, DW Pack, FH Arnold. Lipid-Based Metal Sensor. U.S. Patent 5,616,790. April 1, 1997.
- Kurihara, K, DY Sasaki, T Kunitake. Monolayer Receptor Systems Containing Guanidinium and Nucleobase Functionality. Japan Patent A 4-143481. 1992.
- Sano, M, DY Sasaki, T Kunitake. Epitaxial Growth of Polymeric Thin Films. Japan Patent 3012088. December 10, 1999.
- Yanagi, M, DY Sasaki, K Kurihara, T Kunitake. Detection of ATP Binding to a Functionalized Monolayer by Surface Potential Measurements. Japan Patent 2986899. October 1, 1999.
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| 1994 – present |
Staff Scientist, Sandia National Laboratories |
2003 – 2004;
2009 – present |
Detailee, U.S. Department of Energy, Office of Basic Energy Sciences |
| 1992 – 1994 |
Research Fellow, California Institute of Technology, Department of Chemical Engineering |
| 1989 – 1992 |
Research Scientist, Kunitake Molecular Architecture ERATO Project |
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| 1989 |
PhD, Organic Chemistry, University of California, Irvine, CA |
| 1986 |
MS, Chemistry, University of California, Irvine, CA |
| 1984 |
BS, Chemistry, University of Hawaii at Mãnoa, Honolulul, HI |
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